CD61 (ITGB3) Mouse Monoclonal Antibody [Clone ID: VI-PL2]

CAT#: TA320397

Mouse Anti-Human CD61 (Integrin beta 3) Purified (100 ug)

Product Images

Staining of normal human peripheral blood platelets with 0.06 ug of Mouse IgG1 kappa Isotype Control Purified (left) or 0.06 ug of Anti-Human CD61 (Integrin beta 3) Purified (right) followed by 'F (ab')2 Anti-Mouse IgG PE followed by Anti-Human CD42b FITC.

Specifications

Product Data

• Clone Name: VI-PL2
• Applications: FC
• Recommended Dilution: Flow, IHC, Functional Assay, WB
• Reactivities: Baboon, Canine, Human, Rhesus
• Host: Mouse
• Clonality: Monoclonal
• Formulation: Aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
• Concentration: lot specific
• Purification: Affinity purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: integrin subunit beta 3
• Database Link:
  NP_000203
  Entrez Gene 3690 Human
  UniProt ID P05106
• Background: The VI-PL2 monoclonal antibody reacts with human CD61, also known as integrin beta 3 and GPIIIa. CD61 is a 90-110 kDa member of the beta integrin family expressed by a wide variety of cells, including leukocytes, platelets, endothelial and smooth muscle cells. CD61 binds non-covalently with the alpha integrins CD41 and CD51, to form the alpha IIb beta3 (CD41/CD61) and alpha v beta3 (CD51/CD61) complexes. These alpha beta heterodimers are capable of mediating a variety of cellular responses including adhesion, trafficking, proliferaton and differentiation. The CD41/CD61 integrin has been shown to be involved in platelet aggregation, and binds to fibrinogen, von Willebrand Factor (vWF) and fibronectin. The CD51/CD61 integrin binds to matrix proteins including vitronectin, fibronectin, vWF and fibrinogen, and has been shown to have a strong role in modulating the migration and survival of angiogenic endothelial cells.This VI-PL2 antibody has also been shown to crossreact with canine and several non-human primate species, including baboon, rhesus, and cynomologus monkey.
• Synonyms: BDPLT2; BDPLT16; CD61; GP3A; GPIIIa; GT

Reference Data

• Protein Families: Druggable Genome, ES Cell Differentiation/IPS, Transmembrane
• Protein Pathways: Arrhythmogenic right ventricular cardiomyopathy (ARVC), Dilated cardiomyopathy, ECM-receptor interaction, Focal adhesion, Hematopoietic cell lineage, Hypertrophic cardiomyopathy (HCM), Regulation of actin cytoskeleton