Integrin beta 4 (ITGB4) Rat Monoclonal Antibody [Clone ID: 439-9B]

CAT#: TA320398

Rat Anti-Human CD104 (Integrin beta 4) Purified (100 ug)

Product Images

Staining of the A549 cell line with 0.5 ug of Rat IgG2b K Isotype Control Purified (open histogram) or 0.5 ug of Anti-Human CD104 (Integrin beta 4) Purified (filled histogram) followed by Anti-Rat IgG Biotin and Streptavidin PE. Total viable cells were used for analysis.

Specifications

Product Data

• Clone Name: 439-9B
• Applications: FC
• Recommended Dilution: Flow, IHC, IP, WB
• Reactivities: Human
• Host: Rat
• Clonality: Monoclonal
• Formulation: Aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
• Concentration: lot specific
• Purification: Affinity purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: integrin subunit beta 4
• Database Link:
  NP_000204
  Entrez Gene 3691 Human
  UniProt ID P16144
• Background: The monoclonal antibody 439-9B recognizes human CD104, also known as integrin beta 4. CD104 is a 202 kDa subunit that associates with integrin alpha 6 (CD49f), thereby forming the laminin receptor. Multiple splice variants have been identified. Expression is found on epithelial cells and tumor cells and has been shown to be involved in cell-matrix and cell-cell interactions. The role of CD104 in tumorigenicity is well established. The monoclonal antibody 439-9B has been reported to have no effect on adhesion of human colon adenocarcinoma cells. Moreover, this antibody crossreacts to bovine.
• Synonyms: CD104; GP150

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Arrhythmogenic right ventricular cardiomyopathy (ARVC), Dilated cardiomyopathy, ECM-receptor interaction, Focal adhesion, Hypertrophic cardiomyopathy (HCM), Regulation of actin cytoskeleton