Integrin beta 7 (ITGB7) Rat Monoclonal Antibody [Clone ID: FIB504]

CAT#: TA320399

Rat Anti-Human/Mouse Integrin beta 7 Purified (100 ug)

Product Images

Staining of normal human peripheral blood cells with 0.06 ug of Rat IgG2a kappa Isotype Control Purified (open histogram) or 0.06 ug of Anti-Human/Mouse Integrin ?7 Purified (filled histogram) followed by F (ab')2 Anti-Rat IgG PE. Cells in the lymphocyte gate were used for analysis.

Specifications

Product Data

• Clone Name: FIB504
• Applications: FC
• Recommended Dilution: Flow, Functional Assay
• Reactivities: Human, Mouse
• Host: Rat
• Clonality: Monoclonal
• Formulation: Aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
• Concentration: lot specific
• Purification: Affinity purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: integrin subunit beta 7
• Database Link:
  NP_000880
  Entrez Gene 16421 MouseEntrez Gene 3695 Human
  UniProt ID P26010
• Background: The FIB504 monoclonal antibody reacts with human and mouse integrin beta 7. Integrin beta 7 is a 130 kD glycoprotein which associates with integrin alpha 4 (CD49d) to form the alpha 4 beta 7 integrin LPAM-1, expressed on intraepithelial lymphocytes. It also associates with alpha E (CD103) to form the alpha E beta 7 integrin HML-1, expressed on T cells adjacent to mucosal epithelium and intraepithelial lymphocytes. Main ligands for integrin alpha 4 beta 7 include VCAM-1 (CD106), MAdCAM-1 and fibronectin, while the main ligand of integrin alpha E beta 7 is E-cadherin (CD324). Integrin beta 7 plays an important role in the adhesion of leukocytes to endothelial cells promoting the transmigration of leukocytes to extravascular spaces during the inflammatory response. The FIB504 antibody has been reported to have blocking activity.
• Synonyms: beta 7; integrin; integrin beta 7 subunit

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Arrhythmogenic right ventricular cardiomyopathy (ARVC), Cell adhesion molecules (CAMs), Dilated cardiomyopathy, ECM-receptor interaction, Focal adhesion, Hypertrophic cardiomyopathy (HCM), Regulation of actin cytoskeleton