LMO2 Mouse Monoclonal Antibody [Clone ID: 1A9-3B11]

CAT#: TA320413

Mouse Anti-Human LMO2 Purified (25 ug)

Product Images

Immunohistochemistry of human tonsil tissue at a 1:1000 dilution of Anti-Human LMO2 Purified followed by Anti-Mouse IgG Biotin and avidin HRP and high (right) magnifications are shown.

Specifications

Product Data

• Clone Name: 1A9-3B11
• Applications: IHC
• Recommended Dilution: IHC
• Reactivities: Human
• Host: Mouse
• Clonality: Monoclonal
• Formulation: Aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
• Concentration: lot specific
• Purification: Affinity purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: LIM domain only 2
• Database Link:
  NP_005565
  Entrez Gene 4005 Human
  UniProt ID P25791
• Background: This 1A9-3B11 monoclonal antibody reacts with human LMO2, a member of the LIM-only family of zinc finger proteins. LMO2 possesses two LIM domains for homodimerization and an N-terminal transactivation domain. This 24-kDa transcription factor can be found as part of a transcriptional complex composed of TAL1, E47, GATA-1, and LDB1 proteins. LMO2 is expressed in myeloid cells, germinal center B cells, vascular endothelium, and a variety of cancers, including diffuse large B cell lymphomas (DLBCL), T cell acute lymphoblastic lymphomas, and vascular neoplasms. Expression of LMO2 in germinal center B cells has been shown to be regulated by microRNAs, specifically hsa-miR-223. Although the function of LMO2 remains unclear in germinal center B cells, this factor is involved in hematopoiesis and oncogenesis. In addition, expression of this molecule has been demonstrated to be prognostic marker for survival in DLBCL patients.
• Synonyms: RBTN2; RBTNL1; RHOM2; TTG2

Reference Data

• Protein Families: Druggable Genome