LRRC36 Mouse Monoclonal Antibody [Clone ID: 4F3-3C8-2B7]

CAT#: TA320414

Mouse Anti-Human ROR gamma Purified (25 ug)

Product Images

Lysates prepared from 293 cells (lane 1) and 293 cells transfected with mouse ROR gamma cDNA (lane 2) or human ROR gamma cDNA (lane 3) under reducing conditions with DTT were resolved by SDS-PAGE then immunoblotted with 4 ug/ml of Anti-Human ROR gamma Purified. Bands were visualized using Anti-Mouse IgG HRP.

Specifications

Product Data

• Clone Name: 4F3-3C8-2B7
• Applications: WB
• Recommended Dilution: WB
• Reactivities: Human
• Host: Mouse
• Clonality: Monoclonal
• Formulation: Aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
• Concentration: lot specific
• Purification: Affinity purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: leucine rich repeat containing 36
• Database Link:
  NP_060766
  Entrez Gene 55282 Human
  UniProt ID Q1X8D7
• Background: The 4F3-3G8-2B7 monoclonal antibody reacts with the DNA binding domain of human and mouse RORγ protein. RORγ is a member of the retinoic acid-related orphan receptor (ROR) family, which also includes RORalpha and RORbeta. ROR family proteins are ligand-dependent transcription factors that play roles in multiple physiological processes. RORγ is expressed in several tissues, including liver, lung, muscle, heart and kidney. Furthermore, it was discovered that alternative transcription results in the expression of an isoform, RORγt, that is expressed exclusively in cells of the lymphoid compartment, namely CD4+CD8+ thymoyctes, Th17 cells of the periphery and lymphoid tissue inducer (Lti) cells of lymphoid organs.The RORγt isoform differs from ROR by three unique amino acids at the amino terminus. Therefore, the 4F3-3G8-2 antibody will react with both the RORγ and RORγt isoforms. In addition our data suggests that 4F3-3C8-2B7 has greater sensitivity to human RORγ than to mouse RORγ. For detection of mouse RORγ, please use cat. 14-6981.
• Synonyms: RORBP70; XLHSRF2