MALT1 Mouse Monoclonal Antibody [Clone ID: 50]

CAT#: TA320420

Mouse Anti-Human MALT1 Purified (25 ug)

Product Images

Immunohistochemistry on formalin-fixed paraffin embedded human tonsil tissue with citrate buffer antigen retrieval, using 10 ug/ml of Anti-Human MALT1 Purified (right) or Mouse IgG1 kappa Isotype Control Purified antibody (left) followed by Anti-Mouse Ig Biotin and DAB visualization. Nuclei are counterstained with hematoxylin.

Specifications

Product Data

• Clone Name: 50
• Applications: IHC
• Recommended Dilution: IHC, WB
• Reactivities: Human
• Host: Mouse
• Clonality: Monoclonal
• Formulation: Aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
• Concentration: lot specific
• Purification: Affinity purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: MALT1 paracaspase
• Database Link:
  NP_006776
  Entrez Gene 10892 Human
  UniProt ID Q9UDY8
• Background: The monoclonal antibody 50 recognizes human MALT1 (Mucosal Associated Lymphoid Tissue lymphoma translocation gene 1). MALT1 is a 91 kDa paracaspase that contains a death domain, two Ig-like domains and a C terminal caspase-like domain. Like other caspases, it cleaves substrates after an arginine residue. Expression is found in the cytoplasm of B and T cells. Within B cell follicles, MALT1 expression is highly expressed in centroblasts, followed by centrocytes and weakly expressed in the mantle zone. The interaction of MALT1 and Bcl10 occurs through Ig-like domains resulting in oligomerization and activation of the caspase-like domain. This also directly results in NFκ B activation thereby playing a role in B cell maturation and activation.Rearrangements of the MALT1 gene found in t(11;18)(q21;q21) and t(14;18)(q32;q21) are the most frequent structural chromosomal abnormalities in MALT lymphomas. These translocations lead to fusions of API2(BIRC3)??ALT1 and IGH??ALT1 respectively. An additional translocation between MALT1 and MAP4 has also been identified in DLBCL (diffuse large B- cell lymphoma).The antibody 50 reacts with the C terminal domain of MALT1, which allows for the detection of endogenous MALT1 as well as both identified fusion proteins resulting from translocation events.
• Synonyms: IMD12; MLT; MLT1

Reference Data

• Protein Families: Druggable Genome, Protease
• Protein Pathways: B cell receptor signaling pathway, T cell receptor signaling pathway