Ms4a1 Rat Monoclonal Antibody [Clone ID: AISB12]

CAT#: TA320424

Rat Anti-Mouse CD20 Purified (100 ug)

Product Images

Left: Immunoblot of Balb/c thymus (lane 1) and A20 (lane 2) cell lysates with Anti-Mouse CD20 Purified.

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  Right: Staining of BALB/c splenocytes with Anti-Mouse CD19 Alexa Fluor 647and 1.0 ug Anti-Mouse CD20 Purified followed by Anti-Rat IgG PE. Quadrant lines represent Rat IgG2a isotype control staining levels and cells in the lymphocyte gate were used for analysis.

Specifications

Product Data

• Clone Name: AISB12
• Applications: FC, WB
• Recommended Dilution: Flow, WB
• Reactivities: Mouse
• Host: Rat
• Clonality: Monoclonal
• Formulation: Aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
• Concentration: lot specific
• Purification: Affinity purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: membrane-spanning 4-domains, subfamily A, member 1
• Database Link:
  NP_031667
  Entrez Gene 12482 Mouse
  UniProt ID P19437
• Background: The AISB12 monoclonal antibody reacts with mouse CD20. CD20 is a B cell-specific 32kDa membrane protein involved in intracellular calcium regulation. CD20 expression begins after the induction of CD19 during development, and is coexpressed with IgM during the pre-B to immature B cell transition in bone marrow. Expression then increases during maturation with almost all mature cells expressing some level of CD20. The human CD20 antigen has proven to be an effective immunotherapeutic target in B cell lymphoma and several autoimmune diseases including rheumatoid arthritis and type I diabetes. CD20 consists of 4 transmembrane domains and a 44 amino acid extracellular loop domain where AISB12 binds.
• Synonyms: B1; Bp35; CD20; LEU-16; MGC3969; MS4A2; S7