Pdcd1lg2 Rat Monoclonal Antibody [Clone ID: 122]

CAT#: TA320439

Rat Anti-Mouse CD273 (B7-DC) Purified (50 ug)

Specifications

Product Data

• Clone Name: 122
• Recommended Dilution: Flow
• Reactivities: Mouse
• Host: Rat
• Clonality: Monoclonal
• Formulation: Aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
• Concentration: lot specific
• Purification: Affinity purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: programmed cell death 1 ligand 2
• Database Link:
  NP_067371
  Entrez Gene 58205 Mouse
  UniProt ID Q9WUL5
• Background: The 122 monoclonal antibody reacts with mouse B7-DC, also known as PD-L2. B7-DC, a recently identified member of the B7 family, has a predicted molecular weight of approximately 25 kDa and belongs to the Ig superfamily. The mouse B7-DC has a short cytoplasmic tail (4aa). B7-DC is primarily expressed by subpopulations of dendritic cells and monocytes/macrophages in the mouse. Although B7-DC has structural and sequence similarities to the B7 family, it does not bind CD28/CTLA-4, rather it is a ligand for PD-1. The interactions between PD-1 and B7-DC/PD-L2 have been reported to be involved in costimulation or suppression of T cell proliferation depending on state of cellular activation. 122 has been demonstrated to block binding of TY25 (Cat. No. 14-5986), another mAb specific for mouse B7-DC.
• Synonyms: B7-DC; B7DC; bA574F11.2; Btdc; CD273; MGC142238; MGC142240; PD-L2; PDCD1L2; PDL2