TLR2 Mouse Monoclonal Antibody [Clone ID: TL2.3]

CAT#: TA320481

Mouse Anti-Human CD282 (TLR2) Purified (25 ug)

Product Images

Staining of normal human peripheral blood cells with 0.5 ug of Mouse IgG2a K Isotype Control Purified (open histogram) or 1.0 ug of Anti-Human CD282 (TLR2) Purified (filled histogram) followed by Anti-Mouse IgG FITC. Cells in the monocyte gate were used for analysis.

Specifications

Product Data

• Clone Name: TL2.3
• Applications: FC
• Recommended Dilution: Flow, IHC
• Reactivities: Human
• Host: Mouse
• Clonality: Monoclonal
• Formulation: Aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
• Concentration: lot specific
• Purification: Affinity purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: toll like receptor 2
• Database Link:
  NP_003255
  Entrez Gene 7097 Human
  UniProt ID O60603
• Background: The TL2.3 monoclonal antibody reacts with human Toll-like receptor 2 (TLR2). To date, at least twelve members of the Toll family have been identified in human. This family of type I transmembrane proteins is characterized by an extracellular domain with leucine-rich repeats and a cytoplasmic domain with homology to the type I IL-1 receptor. Two of these receptors, TLR2 and TLR4, are pattern recognition receptors and signaling molecules in response to bacterial lipoproteins and have been implicated in innate immunity and inflammation. TLR2 is expressed by peripheral blood monocytes and is responsible for distinguishing different pathogens. TL2.1 and TL2.3, reported as blocking antibodies, have been used to study the role of TLR2 as a pattern recognition receptor in microbial lipoprotein/lipopeptide induced cytokine production from human peripheral blood mononuclear cells. TL2.3 has been reported to recognize a different epitope than TL2.1 and to work better for detection of TLR2 by immunohistochemistry. TL2.1 and its directly fluorochrome conjugates are more efficient for detection of human TLR2 by flow cytometric analysis.
• Synonyms: CD282; TIL4

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Toll-like receptor signaling pathway