TLR3 Mouse Monoclonal Antibody [Clone ID: TLR3.7]

CAT#: TA320483

Mouse Anti-Human CD283 (TLR3) Purified (25 ug)

Product Images

Staining of permeabilized A549 cell line with 1 ug of Purified Mouse IgG1 kappa Isotype Control (open histogram) or 1 ug of Purified anti-human TLR3 (TLR3.7) (filled histogram) followed by Anti-Mouse IgG FITC. Total cells were used for analysis.

Specifications

Product Data

• Clone Name: TLR3.7
• Applications: FC
• Recommended Dilution: Flow, IHC, IP, WB
• Reactivities: Human
• Host: Mouse
• Clonality: Monoclonal
• Formulation: Aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
• Concentration: lot specific
• Purification: Affinity purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: toll like receptor 3
• Database Link:
  NP_003256
  Entrez Gene 7098 Human
  UniProt ID O15455
• Background: The TLR3.7 monoclonal antibody reacts with human Toll-like receptor 3 (TLR3). To date, at least twelve members of the Toll-like receptor family have been identified. This family of type I transmembrane proteins is characterized by an extracellular domain with leucine-rich repeats and a cytoplasmic domain with homology to the type I IL-1 receptor. In the innate immune response, TLRs recognize molecular patterns associated with microbial pathogens and induce antimicrobial activity. TLR3 recognizes double-stranded (ds)RNA, induces the activation of NF-κB through MyD88-dependent and -independent pathways, and the production of type I interferons (IFNs). TLR3.7 suppressed poly(I):poly(C)-mediated IFN-β production by human fibroblasts naturally expressing TLR3 on their surface.
• Synonyms: CD283; IIAE2

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Toll-like receptor signaling pathway