Tnfrsf11a Rat Monoclonal Antibody [Clone ID: R12-31]

CAT#: TA320494

Rat Anti-Mouse CD265 (RANK) Purified (50 ug)

Specifications

Product Data

• Clone Name: R12-31
• Recommended Dilution: Flow
• Reactivities: Mouse
• Host: Rat
• Clonality: Monoclonal
• Formulation: Aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
• Concentration: lot specific
• Purification: Affinity purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: tumor necrosis factor receptor superfamily, member 11a, NFKB activator
• Database Link:
  NP_033425
  Entrez Gene 21934 Mouse
  UniProt ID O35305
• Background: The R12-31 monoclonal antibody reacts with mouse RANK (Receptor activator of NF-κB), a recently cloned member of the TNFR superfamily with no significant homology to other members of this family. RANK ligand (RANKL/TRANCE/ OPGL) binds to RANK on dendritic cells, upregulates the expression of anti-apoptotic protein BcL-XL suggesting a role in dendritic cell survival. The cytoplasmic domain of RANK interacts with TRAF2, TRAF5 and TRAF6. Overexpression of RANK activates NF-κB and c-Jun-terminal kinase (JNK) pathways. Recent studies have shown that RANK interaction with TRAF6 activates NF-κB, whereas JNK activation is mediated through binding of RANK to TRAF2.
• Synonyms: CD265; FEO; LOH18CR1; ODFR; OFE; OPTB7; OSTS; PDB2; RANK; TRANCER