TWEAKR (TNFRSF12A) Mouse Monoclonal Antibody [Clone ID: ITEM-1]

CAT#: TA320495

Mouse Anti-Human CD266 (TWEAK Receptor) Purified (25 ug)

Product Images

Staining of non-transfected (left) and human Fn14 transfected (right) L5178Y cells with 1.0 ug of Mouse IgG1 kappa Isotype Control Purified (open histogram) or 0.5 ug of Anti-Human CD266 (TWEAK Receptor) Purified (filled histogram) followed by Anti-Mouse IgG FITC. Total viable cells were analyzed.

Specifications

Product Data

• Clone Name: ITEM-1
• Applications: FC
• Recommended Dilution: Flow, IHC, Functional Assay
• Reactivities: Human
• Host: Mouse
• Clonality: Monoclonal
• Formulation: Aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
• Concentration: lot specific
• Purification: Affinity purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: tumor necrosis factor receptor superfamily member 12A
• Database Link:
  NP_057723
  Entrez Gene 51330 Human
  UniProt ID Q9NP84
• Background: The ITEM-1 mAb reacts with human TWEAK Receptor/Fn14 (fibroblast growth factor-inducible 14 kDa protein). Fn14 is distantly related to the TNFR family, containing one cysteine-rich domain in the extracellular region and a TNFR-associated factor binding domain but does not contain a death domain (DD) cytoplasmic region. Fn14 plays a role in TWEAK-induced endothelial cell migration, proliferation, and angiogenesis. TWEAK-induced cell death via Fn14 includes both apoptosis and necrosis and can be blocked by an anti-TWEAK antibody, CARL-1. Fn14 is expressed on HUVEC and in some cancer tissues but not on freshly isolated PBMCs. Fn14 mRNA expression has been identified during liver regeneration.
• Synonyms: CD266; FN14; TWEAKR

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Cytokine-cytokine receptor interaction