Angiotensinogen (AGT) Rabbit Polyclonal Antibody

CAT#: TA321038

Anti-AGT Rabbit Polyclonal Antibody


USD 345.00

In Stock*

Size
    • 100 ul

Product Images

Specifications

Product Data
Applications WB
Recommended Dilution WB: 500-2000
WB positive control: Human liver cancer tissue
Reactivities Human, Mouse, Rat
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen Synthetic peptide peptide corresponding to a region derived from 34-41 amino acids of human angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
Formulation PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration lot specific
Purification Antigen affinity purification
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Predicted Protein Size 53 kDa
Gene Name angiotensinogen
Background The protein encoded by this gene; pre-angiotensinogen or angiotensinogen precursor; is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product; angiotensin I; is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension; and can cause renal tubular dysgenesis; a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation; and inflammatory bowel disease.
Synonyms ANHU; SERPINA8
Reference Data
Protein Families Druggable Genome, Secreted Protein
Protein Pathways Renin-angiotensin system

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