Cystatin C (CST3) Rabbit Polyclonal Antibody

CAT#: TA321058

Anti-CST3 Rabbit Polyclonal Antibody

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB: 1000-5000
  WB positive control: Human fetal brain tissue
  IHC: 50-200
  Positive control: Human gasrtic cancer
  Predicted cell location: Cytoplasm
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to a region derived from 102-118 amino acids of Human cystatin C
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 16 kDa
• Gene Name: cystatin C
• Database Link:
  NP_000090
  Entrez Gene 13010 MouseEntrez Gene 25307 RatEntrez Gene 1471 Human
  UniProt ID P01034
• Background: The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors; while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily; including the type 1 cystatins (stefins); type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions; where they appear to provide protective functions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes the most abundant extracellular inhibitor of cysteine proteases; which is found in high concentrations in biological fluids and is expressed in virtually all organs of the body. A mutation in this gene has been associated with amyloid angiopathy. Expression of this protein in vascular wall smooth muscle cells is severely reduced in both atherosclerotic and aneurysmal aortic lesions; establishing its role in vascular disease.
• Synonyms: ARMD11; HEL-S-2

Reference Data

• Protein Families: Druggable Genome, ES Cell Differentiation/IPS, Transmembrane