alpha Synuclein (SNCA) Rabbit Polyclonal Antibody

CAT#: TA321111

Anti-SNCA (Phospho-Tyr125) Rabbit Polyclonal Antibody


USD 345.00

4 Weeks*

Size
    • 100 ul

Product Images

Other products for "SNCA"

Specifications

Product Data
Applications IF, WB
Recommended Dilution WB: 1:500-1000, IF: 1:100-200
Reactivities Human
Modifications Phospho-specific
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen Peptide sequence around phosphorylation site of tyrosine 125 (E-A-Y(p)-E-M) derived from Human a-Synuclein.
Formulation PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration lot specific
Purification Antigen affinity purification
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Predicted Protein Size 18 kDa
Gene Name synuclein alpha
Background SncA is a member of the synuclein family of structurally related proteins that are prominently expressed in the central nervous system, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and SncA and Snc-Beta inhibit phospholipase D2 selectively. SncA may serve to integrate presynaptic signaling and membrane trafficking. Aggregated SncA proteins form brain lesions that are hallmarks of neurodegenerative synucleinopathies. Defects in SncA play a role in the pathogenesis of Parkinson disease. SncA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer disease. SncA shares 95% sequence homology with rat SncA. Rat SncA is specifically expressed in brain and is associated with synaptosomal membranes in neurons
Synonyms NACP; PARK1; PARK4; PD1
Reference Data
Protein Families Druggable Genome
Protein Pathways Alzheimer's disease, Parkinson's disease

{0} Product Review(s)

0 Product Review(s) Submit review

Be the first one to submit a review

Product Citations

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.