Prealbumin (TTR) Rabbit Polyclonal Antibody

CAT#: TA321118

Anti-TTR Rabbit Polyclonal Antibody

Specifications

Product Data

• Applications: ELISA, IHC
• Recommended Dilution: IHC: 50-200
  Positive control: Human ovarian cancer
  Predicted cell location: Secreted
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Full length fusion protein
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: transthyretin
• Database Link:
  NP_000362
  Entrez Gene 22139 MouseEntrez Gene 24856 RatEntrez Gene 7276 Human
  UniProt ID P02766
• Background: This gene encodes transthyretin; one of the three prealbumins including alpha-1-antitrypsin; transthyretin and orosomucoid. Transthyretin is a carrier protein; it transports thyroid hormones in the plasma and cerebrospinal fluid; and also transports retinol (vitamin A) in the plasma. The protein consists of a tetramer of identical subunits. More than 80 different mutations in this gene have been reported; most mutations are related to amyloid deposition; affecting predominantly peripheral nerve and/or the heart; and a small portion of the gene mutations is non-amyloidogenic. The diseases caused by mutations include amyloidotic polyneuropathy; euthyroid hyperthyroxinaemia; amyloidotic vitreous opacities; cardiomyopathy; oculoleptomeningeal amyloidosis; meningocerebrovascular amyloidosis; carpal tunnel syndrome; etc.
• Synonyms: CTS; CTS1; HEL111; HsT2651; PALB; TBPA

Reference Data

• Protein Families: ES Cell Differentiation/IPS, Secreted Protein