HNF 4 alpha (HNF4A) Rabbit Polyclonal Antibody

CAT#: TA321134

Anti-HNF4A Rabbit Polyclonal Antibody

Product Images

Predicted band size: 52 kDa. Positive control: Mouse liver and Kidney tissue lysate. Recommended dilution: 1/500-2000. (Gel: 10%SDS-PAGE Lane 1: Mouse liver tissue lysate Lane 2: Mouse Kidney tissue lysate Lysates: 40 ug per lane Primary antibody: 1/500 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 minute)

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1:500-2000
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to a region derived from 241-254 amino acids of human hepatocyte nuclear factor 4, alpha
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 52 kDa
• Gene Name: hepatocyte nuclear factor 4 alpha
• Database Link:
  NP_000448
  Entrez Gene 15378 MouseEntrez Gene 25735 RatEntrez Gene 3172 Human
  UniProt ID P41235
• Background: Hepatocyte nuclear factor 4a (HNF4a) is a transcription factor that belongs to the steroid hormone receptor superfamily and is enriched in liver. HNF4a, in association with PGC-1a, activates gluconeogenic genes such as phosphoenolpyruvate carboxykinase and glucose-6-phosphatase genes in fasted livers. Conditional knockout of the HNF4a gene in the mouse liver destroys lipid homeostasis and leads to lipid accumulation in the liver and a reduction of serum cholesterol and triglyceride levels. Mutations in HNF4a have been linked to maturity-onset diabetes of the young (MODY).
• Synonyms: FRTS4; HNF4; HNF4a7; HNF4a8; HNF4a9; HNF4alpha; MODY; MODY1; NR2A1; NR2A21; TCF; TCF14

Reference Data

• Protein Families: Druggable Genome, ES Cell Differentiation/IPS, Nuclear Hormone Receptor, Transcription Factors
• Protein Pathways: Maturity onset diabetes of the young