Alkaline Phosphatase (ALPL) Rabbit Polyclonal Antibody

CAT#: TA321138

Anti-ALPL Rabbit Polyclonal Antibody


USD 345.00

4 Weeks*

Size
    • 100 ul

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Specifications

Product Data
Applications IHC
Recommended Dilution IHC: 200-400
Positive control: Human esophagus cancer
Predicted cell location: Cytoplasm
Reactivities Human, Mouse, Rat
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen Fusion protein corresponding to a region derived from 2-329 amino acids of Human Alkaline phosphatase
Formulation PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration lot specific
Purification Antigen affinity purification
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Gene Name alkaline phosphatase, liver/bone/kidney
Background There are at least four distinct but related alkaline phosphatases: intestinal; placental; placental-like; and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2; while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is; therefore; referred to as the tissue-nonspecific form of the enzyme. The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the enzyme is matrix mineralization; however; mice that lack a functional form of this enzyme show normal skeletal development. This enzyme has been linked directly to hypophosphatasia; a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of this disorder can vary; however; depending on the specific mutation since this determines age of onset and severity of symptoms. Alternatively spliced transcript variants have been described.
Synonyms AP-TNAP; APTNAP; HOPS; TNAP; TNSALP
Reference Data
Protein Families Druggable Genome
Protein Pathways Folate biosynthesis, Metabolic pathways

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.