Alkaline Phosphatase (ALPL) Rabbit Polyclonal Antibody

CAT#: TA321138

Anti-ALPL Rabbit Polyclonal Antibody

Product Images

Immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using TA321138 (ALPL Antibody) at dilution 1/240 (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using TA321138 (ALPL Antibody) at dilution 1/240, treated with fusion protein. (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human liver cancer tissue using TA321138 (ALPL Antibody) at dilution 1/240 (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human liver cancer tissue using TA321138 (ALPL Antibody) at dilution 1/240, treated with fusion protein. (Original magnification: ×200)

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: IHC: 200-400
  Positive control: Human esophagus cancer
  Predicted cell location: Cytoplasm
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Fusion protein corresponding to a region derived from 2-329 amino acids of Human Alkaline phosphatase
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: alkaline phosphatase, liver/bone/kidney
• Database Link:
  NP_000469
  Entrez Gene 11647 MouseEntrez Gene 25586 RatEntrez Gene 249 Human
  UniProt ID P05186
• Background: There are at least four distinct but related alkaline phosphatases: intestinal; placental; placental-like; and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2; while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is; therefore; referred to as the tissue-nonspecific form of the enzyme. The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the enzyme is matrix mineralization; however; mice that lack a functional form of this enzyme show normal skeletal development. This enzyme has been linked directly to hypophosphatasia; a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of this disorder can vary; however; depending on the specific mutation since this determines age of onset and severity of symptoms. Alternatively spliced transcript variants have been described.
• Synonyms: AP-TNAP; APTNAP; HOPS; TNAP; TNSALP

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Folate biosynthesis, Metabolic pathways