IGF1 Receptor (IGF1R) Rabbit Polyclonal Antibody

CAT#: TA321219

Anti-IGF1R (Phospho-Tyr1165/Tyr1166) Rabbit Polyclonal Antibody

Product Images

Predicted band size: 155 kDa. Positive control: 293 cells treated with insulin lysate. Recommended dilution: 1/ 500-1000. (Gel: 8%SDS-PAGE Lane 1: 293 cells untreated with insulin lysate Lane 2: 293 cells treated with insulin lysate Lysates: 30 ug per lane Primary antibody: 1/500 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 minute)

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  Predicted cell location: Cell membrane. Positive control: MCF cells. Recommended dilution: 1/ 100-200.The image is immunofluorescence of methanol-fixed MCF cells using IGF1R (Phospho-Tyr1165/Tyr1166) antibody at dilution 1/100. (Original magnification:×200)

Specifications

Product Data

• Applications: IF, WB
• Recommended Dilution: WB: 1:500-1000, IF: 1:100-200
• Reactivities: Human, Mouse, Rat
• Modifications: Phospho-specific
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Peptide sequence around phosphorylation site of tyrosine 1165/tyrosine 1166 (T-D-Y(p)-Y(p)-R-K) derived from Human IGF-1R .
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 155 kDa
• Gene Name: insulin like growth factor 1 receptor
• Database Link:
  NP_000866
  Entrez Gene 16001 MouseEntrez Gene 25718 RatEntrez Gene 3480 Human
  UniProt ID P08069
• Background: This receptor binds insulin-like growth factor 1 (IGF1) with a high affinity and IGF2 with a lower affinity. It has a tyrosine-protein kinase activity, which is necessary for the activation of the IGF1-stimulated downstream signaling cascade. When present in a hybrid receptor with INSR, binds IGF1.
• Synonyms: CD221; IGFIR; IGFR; JTK13

Reference Data

• Protein Families: Druggable Genome, Protein Kinase, Transmembrane
• Protein Pathways: Adherens junction, Colorectal cancer, Endocytosis, Focal adhesion, Glioma, Long-term depression, Melanoma, Oocyte meiosis, Pathways in cancer, Progesterone-mediated oocyte maturation, Prostate cancer