EP4 (PTGER4) Rabbit Polyclonal Antibody

CAT#: TA321244

Anti-PTGER4 Rabbit Polyclonal Antibody

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 500-2000
  WB positive control: LoVo cells
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to a region derived from 458-473 amino acids of Human prostaglandin E receptor 4 (subtype EP4)
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 53 kDa
• Gene Name: prostaglandin E receptor 4
• Database Link:
  NP_000949
  Entrez Gene 19219 MouseEntrez Gene 84023 RatEntrez Gene 5734 Human
  UniProt ID P35408
• Background: The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor can activate T-cell factor signaling. It has been shown to mediate PGE2 induced expression of early growth response 1 (EGR1); regulate the level and stability of cyclooxygenase-2 mRNA; and lead to the phosphorylation of glycogen synthase kinase-3. Knockout studies in mice suggest that this receptor may be involved in the neonatal adaptation of circulatory system; osteoporosis; as well as initiation of skin immune responses.
• Synonyms: EP4; EP4R

Reference Data

• Protein Families: Druggable Genome, GPCR, Transmembrane
• Protein Pathways: Neuroactive ligand-receptor interaction