PAF Receptor (PTAFR) Rabbit Polyclonal Antibody

CAT#: TA321248

Anti-PTAFR Rabbit Polyclonal Antibody


USD 345.00

In Stock*

Size
    • 100 ul

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Specifications

Product Data
Applications IHC
Recommended Dilution IHC: 25-100
Positive control: Human gasrtic cancer
Predicted cell location: Cytoplasm
Reactivities Human, Mouse, Rat
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen Synthetic peptide corresponding to a region derived from 1-14 amino acids of Human platelet-activating factor receptor
Formulation PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration lot specific
Purification Antigen affinity purification
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Gene Name platelet activating factor receptor
Background This gene encodes a seven-transmembrane G-protein-coupled receptor for platelet-activating factor (PAF) that localizes to lipid rafts and/or caveolae in the cell membrane. PAF (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) is a phospholipid that plays a significant role in oncogenic transformation; tumor growth; angiogenesis; metastasis; and pro-inflammatory processes. Binding of PAF to the PAF-receptor (PAFR) stimulates numerous signal transduction pathways including phospholipase C; D; A2; mitogen-activated protein kinases (MAPKs); and the phosphatidylinositol-calcium second messenger system. Following PAFR activation; cells become rapidly desensitized and this refractory state is dependent on PAFR phosphorylation; internalization; and down-regulation. Alternative splicing results in multiple transcript variants.
Synonyms PAFR
Reference Data
Protein Families Druggable Genome, GPCR, Transmembrane
Protein Pathways Calcium signaling pathway, Neuroactive ligand-receptor interaction

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