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TNFRSF1B Rabbit Polyclonal Antibody
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Other products for "TNFRSF1B"
Specifications
| Product Data | |
| Applications | WB |
| Recommended Dilution | WB: 200-1000 WB positive control: Human colon cancer |
| Reactivities | Human, Mouse, Rat |
| Host | Rabbit |
| Isotype | IgG |
| Clonality | Polyclonal |
| Immunogen | Fusion protein corresponding to a region derived from 291-461 amino acids of human tumor necrosis factor receptor superfamily, member 1B |
| Formulation | PBS pH7.3, 0.05% NaN3, 50% glycerol |
| Concentration | lot specific |
| Purification | Antigen affinity purification |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Predicted Protein Size | 48 kDa |
| Gene Name | tumor necrosis factor receptor superfamily member 1B |
| Database Link | |
| Background | The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins; c-IAP1 and c-IAP2; which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown; however; c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2; which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. |
| Synonyms | CD120b; p75; p75TNFR; TBPII; TNF-R-II; TNF-R75; TNFBR; TNFR1B; TNFR2; TNFR80 |
| Reference Data | |
| Protein Families | Druggable Genome, Secreted Protein, Transmembrane |
| Protein Pathways | Adipocytokine signaling pathway, Amyotrophic lateral sclerosis (ALS), Cytokine-cytokine receptor interaction |
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