DUSP4 Rabbit Polyclonal Antibody

CAT#: TA321338

Anti-DUSP4 Rabbit Polyclonal Antibody

Specifications

Product Data

• Applications: ELISA, IHC, WB
• Recommended Dilution: WB: 200-1000
  WB positive control: LO2 cells
  IHC: 50-200
  Positive control: Human gasrtic cancer
  Predicted cell location: Nucleus
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Fusion protein corresponding to a region derived from 197-394 amino acids of human dual specificity phosphatase 4
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 43 kDa
• Gene Name: dual specificity phosphatase 4
• Database Link:
  NP_001385
  Entrez Gene 60587 RatEntrez Gene 319520 MouseEntrez Gene 1846 Human
  UniProt ID Q13115
• Background: The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK; SAPK/JNK; p38); which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases; different tissue distribution and subcellular localization; and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1; ERK2 and JNK; is expressed in a variety of tissues; and is localized in the nucleus. Two alternatively spliced transcript variants; encoding distinct isoforms; have been observed for this gene. In addition; multiple polyadenylation sites have been reported.
• Synonyms: HVH2; MKP-2; MKP2; TYP

Reference Data

• Protein Families: Phosphatase
• Protein Pathways: MAPK signaling pathway