FOXO3 Rabbit Polyclonal Antibody

CAT#: TA321349

Anti-FOXO3 Rabbit Polyclonal Antibody

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: IHC: 50-150
  Positive control: Human cervical cancer
  Predicted cell location: Cytoplasm, Nucleus
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to a region derived from 442-454 amino acids of Human forkhead box O3
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: forkhead box O3
• Database Link:
  NP_001446
  Entrez Gene 56484 MouseEntrez Gene 294515 RatEntrez Gene 2309 Human
  UniProt ID O43524
• Background: This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same protein have been observed. Interacts with YWHAB/14-3-3-beta and YWHAZ/14-3-3-zeta; which are required for cytosolic sequestration. Upon oxidative stress; interacts with STK4/MST1; which disrupts interaction with YWHAB/14-3-3-beta and leads to nuclear translocation. Interacts with PIM1. Interacts with DDIT3/CHOP.
• Synonyms: AF6q21; FKHRL1; FKHRL1P2; FOXO2; FOXO3A

Reference Data

• Protein Families: Druggable Genome, Transcription Factors
• Protein Pathways: Chemokine signaling pathway, Endometrial cancer, Neurotrophin signaling pathway, Non-small cell lung cancer