FOXO3 Rabbit Polyclonal Antibody

CAT#: TA321349

Anti-FOXO3 Rabbit Polyclonal Antibody


USD 345.00

In Stock*

Size
    • 100 ul

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Specifications

Product Data
Applications IHC
Recommended Dilution IHC: 50-150
Positive control: Human cervical cancer
Predicted cell location: Cytoplasm, Nucleus
Reactivities Human, Mouse, Rat
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen Synthetic peptide corresponding to a region derived from 442-454 amino acids of Human forkhead box O3
Formulation PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration lot specific
Purification Antigen affinity purification
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Gene Name forkhead box O3
Background This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same protein have been observed. Interacts with YWHAB/14-3-3-beta and YWHAZ/14-3-3-zeta; which are required for cytosolic sequestration. Upon oxidative stress; interacts with STK4/MST1; which disrupts interaction with YWHAB/14-3-3-beta and leads to nuclear translocation. Interacts with PIM1. Interacts with DDIT3/CHOP.
Synonyms AF6q21; FKHRL1; FKHRL1P2; FOXO2; FOXO3A
Reference Data
Protein Families Druggable Genome, Transcription Factors
Protein Pathways Chemokine signaling pathway, Endometrial cancer, Neurotrophin signaling pathway, Non-small cell lung cancer

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