GLP1R Rabbit Polyclonal Antibody

CAT#: TA321428

Anti-GLP1R Rabbit Polyclonal Antibody

Product Images

Immunohistochemistry of paraffin-embedded Human renal cancer tissue using TA321428 (GLP1R Antibody) at dilution 1/20 (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human renal cancer tissue using TA321428 (GLP1R Antibody) at dilution 1/20, treated with fusion protein. (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human brain tissue using TA321428 (GLP1R Antibody) at dilution 1/20 (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human brain tissue using TA321428 (GLP1R Antibody) at dilution 1/20, treated with fusion protein. (Original magnification: ×200)

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: IHC: 25-100
  Positive control: Human renal cancer
  Predicted cell location: Cytoplasm, Cell membrane
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Fusion protein corresponding to a region derived from 24-145 amino acids of human glucagon-like peptide 1 receptor
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: glucagon like peptide 1 receptor
• Database Link:
  NP_002053
  Entrez Gene 14652 MouseEntrez Gene 25051 RatEntrez Gene 2740 Human
  UniProt ID P43220
• Background: The glucagon-like peptide 1 receptor (GLP1R) is a human gene which resides on chromosome 6.The protein encoded by this gene is a member of the glucagon receptor family of G protein-coupled receptors. GLP1R binds specifically the glucagon-like peptide-1 (GLP1) and has much lower affinity for related peptides such as the gastric inhibitory polypeptide and glucagon. GLP1R is known to be expressed in pancreatic beta cells. Activated GLP1R stimulates the adenylyl cyclase pathway which results in increased insulin synthesis and release of insulin. Consequently GLP1R has been suggested as a potential target for the treatment of diabetes.
• Synonyms: MGC138331

Reference Data

• Protein Families: Druggable Genome, ES Cell Differentiation/IPS, GPCR, Transmembrane
• Protein Pathways: Neuroactive ligand-receptor interaction