Inhibin beta A (INHBA) Rabbit Polyclonal Antibody

CAT#: TA321447

Anti-INHBA Rabbit Polyclonal Antibody

Product Images

Gel: 8+10%SDS-PAGE Lysate: 30 μg Lane: Mouse fat tissue Primary antibody: TA321447 (INHBA Antibody) at dilution 1/1000 Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution Exposure time: 10 seconds

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB: 500-2000
  WB positive control: Human fetal brain tissue
  IHC: 25-100
  Positive control: Human colon cancer
  Predicted cell location: Cytoplasm
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to a region derived from 375-390 amino acids of Human Inhibin beta A chain
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 47 kDa
• Gene Name: inhibin beta A subunit
• Database Link:
  NP_002183
  Entrez Gene 16323 MouseEntrez Gene 29200 RatEntrez Gene 3624 Human
  UniProt ID P08476
• Background: The inhibin beta A subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumor-suppressor activity. In addition; serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion; it is proposed that inhibin may be both a growth/differentiation factor and a hormone. Furthermore; the beta A subunit forms a homodimer; activin A; and also joins with a beta B subunit to form a heterodimer; activin AB; both of which stimulate FSH secretion. Finally; it has been shown that the beta A subunit mRNA is identical to the erythroid differentiation factor subunit mRNA and that only one gene for this mRNA exists in the human genome.
• Synonyms: EDF; FRP

Reference Data

• Protein Families: Druggable Genome, Secreted Protein
• Protein Pathways: Cytokine-cytokine receptor interaction, TGF-beta signaling pathway