PDK2 Rabbit Polyclonal Antibody

CAT#: TA321505

Anti-PDK2 Rabbit Polyclonal Antibody

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB: 200-1000
  WB positive control: Mouse heart tissue
  IHC: 50-200
  Positive control: Human liver cancer
  Predicted cell location: Mitochondrion matrix, Cytoplasm
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to a region derived from 10-24 amino acids of human pyruvate dehydrogenase kinase, isozyme 2
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 46 kDa
• Gene Name: pyruvate dehydrogenase kinase 2
• Database Link:
  NP_002602
  Entrez Gene 18604 MouseEntrez Gene 81530 RatEntrez Gene 5164 Human
  UniProt ID Q15119
• Background: This gene encodes a member of the pyruvate dehydrogenase kinase family. The encoded protein phosphorylates pyruvate dehydrogenase; down-regulating the activity of the mitochondrial pyruvate dehydrogenase complex. Overexpression of this gene may play a role in both cancer and diabetes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
• Synonyms: PDHK2; PDKII

Reference Data

• Protein Families: Druggable Genome, Protein Kinase