SOCS3 Rabbit Polyclonal Antibody

CAT#: TA321612

Anti-SOCS3 Rabbit Polyclonal Antibody

Specifications

Product Data

• Applications: ELISA, IHC, WB
• Recommended Dilution: WB: 500-2000
  WB positive control: Mouse heart tissue
  IHC: 25-100
  Positive control: Human liver cancer
  Predicted cell location: Cytoplasm
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Full length fusion protein
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: suppressor of cytokine signaling 3
• Database Link:
  NP_003946
  Entrez Gene 12702 MouseEntrez Gene 89829 RatEntrez Gene 9021 Human
  UniProt ID O14543
• Background: This gene encodes a member of the STAT-induced STAT inhibitor (SSI); also known as suppressor of cytokine signaling (SOCS); family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene is induced by various cytokines; including IL6; IL10; and interferon (IFN)-gamma. The protein encoded by this gene can bind to JAK2 kinase; and inhibit the activity of JAK2 kinase. Studies of the mouse counterpart of this gene suggested the roles of this gene in the negative regulation of fetal liver hematopoiesis; and placental development.
• Synonyms: ATOD4; CIS3; Cish3; SOCS-3; SSI-3; SSI3

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Adipocytokine signaling pathway, Insulin signaling pathway, Jak-STAT signaling pathway, Type II diabetes mellitus, Ubiquitin mediated proteolysis