Grp75 (HSPA9) Rabbit Polyclonal Antibody

CAT#: TA321626

Anti-HSPA9 Rabbit Polyclonal Antibody

Product Images

Predicted band size: 74 kDa. Positive control: MCF7, K562, HeLa and Jurkat cell lysate. Recommended dilution: 1/500-2000. (Gel: 8%SDS-PAGE Lane 1: MCF7 cell lysate Lane 2: K562 cell lysate Lane 3: HeLa cell lysate Lane 4: Jurkat cell lysate Lysates: 40 ug per lane Primary antibody: 1/500 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 minute)

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1:500-2000
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Fusion protein corresponding to C terminal 300 amino acids of human heat shock 70kDa protein 9 (mortalin)
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 74 kDa
• Gene Name: heat shock protein family A (Hsp70) member 9
• Database Link:
  NP_004125
  Entrez Gene 15526 MouseEntrez Gene 291671 RatEntrez Gene 3313 Human
  UniProt ID P38646
• Background: Grp75, also known as mortalin, is a member of Hsp70 family of chaperone proteins that is not heat-inducible. This protein is essential for transporting many mitochondrial proteins from the cytoplasm to mitochondria. Grp75 inactivates the tumor suppressor p53. Studies found that Grp75 is overexpressed in many tumor tissues and immortalized human cell lines, suggesting its role in the tumor formation. Grp75 is also implicated in cell aging, as its overexpression appears to prolong the life span of human fibroblasts.
• Synonyms: CSA; GRP-75; GRP75; HEL-S-124m; HSPA9B; MOT; MOT2; MTHSP75; PBP74

Reference Data

• Protein Families: Stem cell - Pluripotency
• Protein Pathways: RNA degradation