RAMP2 Rabbit Polyclonal Antibody

CAT#: TA321729

Anti-RAMP2 Rabbit Polyclonal Antibody

Product Images

Gel: 10%SDS-PAGE Lysate: 40 μg Lane: 231 cells Primary antibody: TA321729 (RAMP2 Antibody) at dilution 1/650 Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution Exposure time: 5 minutes

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 500-2000
  WB positive control: 231 cells
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to a region derived from 71-84 amino acids of Human receptor (G protein-coupled) activity modifying protein 2
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 20 kDa
• Gene Name: receptor activity modifying protein 2
• Database Link:
  NP_005845
  Entrez Gene 54409 MouseEntrez Gene 58966 RatEntrez Gene 10266 Human
  UniProt ID O60895
• Background: The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins; called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR; a receptor with seven transmembrane domains; can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor; depending on which members of the RAMP family are expressed. In the presence of this (RAMP2) protein; CRLR functions as an adrenomedullin receptor. The RAMP2 protein is involved in core glycosylation and transportation of adrenomedullin receptor to the cell surface.
• Synonyms: RAMP2

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Vascular smooth muscle contraction