Melatonin Receptor 1A (MTNR1A) Rabbit Polyclonal Antibody

CAT#: TA321735

Anti-MTNR1A Rabbit Polyclonal Antibody

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB: 500-2000
  WB positive control: SP20 cell lysate
  IHC: 30-150
  Positive control: Human colorectal cancer
  Predicted cell location: Cell membrane
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide peptide corresponding to a region derived from 130-144 amino acids of human melatonin receptor 1A
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 39 kDa
• Gene Name: melatonin receptor 1A
• Database Link:
  NP_005949
  Entrez Gene 17773 MouseEntrez Gene 114211 RatEntrez Gene 4543 Human
  UniProt ID P48039
• Background: This gene encodes one of two high affinity forms of a receptor for melatonin; the primary hormone secreted by the pineal gland. This receptor is a G-protein coupled; 7-transmembrane receptor that is responsible for melatonin effects on mammalian circadian rhythm and reproductive alterations affected by day length. The receptor is an integral membrane protein that is readily detectable and localized to two specific regions of the brain. The hypothalamic suprachiasmatic nucleus appears to be involved in circadian rhythm while the hypophysial pars tuberalis may be responsible for the reproductive effects of melatonin.
• Synonyms: MEL-1A-R; MT1

Reference Data

• Protein Families: Druggable Genome, GPCR, Transmembrane
• Protein Pathways: Neuroactive ligand-receptor interaction