CD90 (THY1) Rabbit Polyclonal Antibody

CAT#: TA321756

Anti-THY1 Rabbit Polyclonal Antibody

Product Images

Predicted band size: 18 kDa. Positive control: Human fetal brain tissue lysate. Recommended dilution: 1/500-2000. (Gel: 12%SDS-PAGE Lysate: 40 ug Primary antibody: 1/500 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 minute)

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1:500-2000
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to a region derived from 51-65 amino acids of human Thy-1 cell surface antigen
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 18 kDa
• Gene Name: Thy-1 cell surface antigen
• Database Link:
  NP_006279
  Entrez Gene 21838 MouseEntrez Gene 24832 RatEntrez Gene 7070 Human
  UniProt ID P04216
• Background: Thy1 is a GPI-anchored, developmentally regulated protein involved in various signaling cascades that mediate neurite outgrowth, T cell activation, tumor suppression, apoptosis, and fibrosis. It is highly expressed on the surface of adult neurons and is thought to play a role in modulating adhesive and migratory events, such as neurite extension. Decreased Thy1 expression is associated with the development of epithelial ovarian cancer, revealing its role as a putative tumor suppressor gene of human ovarian cancer. Thy1 knockout mice have impaired cutaneous immune responses and abnormal retinal development. Thy1 is epigenetically regulated, or deregulated in some disease states, such as pulmonary fibrosis. The potentially reversible hypermethylation of the Thy1 promoter offers the possibility of novel therapeutic options in this disease).
• Synonyms: CD90; CDw90

Reference Data

• Protein Families: ES Cell Differentiation/IPS
• Protein Pathways: Leukocyte transendothelial migration