Fibulin 5 (FBLN5) Rabbit Polyclonal Antibody

CAT#: TA321761

Anti-FBLN5 Rabbit Polyclonal Antibody


USD 345.00

In Stock*

Size
    • 100 ul

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Specifications

Product Data
Applications IHC
Recommended Dilution IHC: 50-200
Positive control: Human lung cancer
Predicted cell location: Cytoplasm
Reactivities Human, Mouse, Rat
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen Synthetic peptide corresponding to a region derived from 408-422 amino acids of Human fibulin 5
Formulation PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration lot specific
Purification Antigen affinity purification
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Gene Name fibulin 5
Background The protein encoded by this gene is a secreted; extracellular matrix protein containing an Arg-Gly-Asp (RGD) motif and calcium-binding EGF-like domains. It promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. It is prominently expressed in developing arteries but less so in adult vessels. However; its expression is reinduced in balloon-injured vessels and atherosclerotic lesions; notably in intimal vascular smooth muscle cells and endothelial cells. Therefore; the protein encoded by this gene may play a role in vascular development and remodeling. Defects in this gene are a cause of autosomal dominant cutis laxa; autosomal recessive cutis laxa type I (CL type I); and age-related macular degeneration type 3 (ARMD3).
Synonyms ADCL2; ARCL1A; ARMD3; DANCE; EVEC; FIBL-5; HNARMD; UP50
Reference Data
Protein Families Secreted Protein

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