PTP epsilon (PTPRE) Rabbit Polyclonal Antibody

CAT#: TA321768

Anti-PTPRE Rabbit Polyclonal Antibody


USD 345.00

In Stock*

Size
    • 100 ul

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Specifications

Product Data
Applications IHC
Recommended Dilution IHC: 15-50
Positive control: Human breast cancer
Predicted cell location: Cytoplasm
Reactivities Human, Mouse, Rat
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen Fusion protein corresponding to a region derived from 426-689 amino acids of human protein tyrosine phosphatase, receptor type, E
Formulation PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration lot specific
Purification Antigen affinity purification
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Gene Name protein tyrosine phosphatase, receptor type E
Background The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth; differentiation; mitotic cycle; and oncogenic transformation. Two alternatively spliced transcript variants of this gene have been reported; one of which encodes a receptor-type PTP that possesses a short extracellular domain; a single transmembrane region; and two tandem intracytoplasmic catalytic domains; Another one encodes a PTP that contains a distinct hydrophilic N-terminus; and thus represents a nonreceptor-type isoform of this PTP. Studies of the similar gene in mice suggested the regulatory roles of this PTP in RAS related signal transduction pathways; cytokines induced SATA signaling; as well as the activation of voltage-gated K+ channels.
Synonyms HPTPE; PTPE; R-PTP-EPSILON
Reference Data
Protein Families Druggable Genome, Phosphatase, Transmembrane

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