GJB6 Rabbit Polyclonal Antibody

CAT#: TA321788

Anti-GJB6 Rabbit Polyclonal Antibody

Product Images

Immunohistochemistry of paraffin-embedded Human tonsil tissue using TA321788 (GJB6 Antibody) at dilution 1/40 (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human tonsil tissue using TA321788 (GJB6 Antibody) at dilution 1/40, treated with synthetic peptide. (Original magnification: ×200)

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: IHC: 25-100
  Positive control: Human tonsil
  Predicted cell location: Cytoplasm
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to a region derived from 247-261 amino acids of Human gap junction protein, beta 6, 30kDa
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: gap junction protein beta 6
• Database Link:
  NP_006774
  Entrez Gene 14623 MouseEntrez Gene 84403 RatEntrez Gene 10804 Human
  UniProt ID O95452
• Background: Gap junctions allow the transport of ions and metabolites between the cytoplasm of adjacent cells. They are formed by two hemichannels; made up of six connexin proteins assembled in groups. Each connexin protein has four transmembrane segments; two extracellular loops; a cytoplasmic loop formed between the two inner transmembrane segments; and the N- and C-terminus both being in the cytoplasm. The specificity of the gap junction is determined by which connexin proteins comprise the hemichannel. In the past; connexin protein names were based on their molecular weight; however the new nomenclature uses sequential numbers based on which form (alpha or beta) of the gap junction is present. This gene encodes one of the connexin proteins. Mutations in this gene have been found in some forms of deafness and in some families with hidrotic ectodermal dysplasia.
• Synonyms: CX30; DFNA3; DFNA3B; DFNB1B; ECTD2; ED2; EDH; HED; HED2

Reference Data

• Protein Families: Druggable Genome, Transmembrane