MALT1 Rabbit Polyclonal Antibody

CAT#: TA321789

Anti-MALT1 Rabbit Polyclonal Antibody

Product Images

Predicted band size: 92 kDa. Positive control: Jurkat and K562 cell, bone marrow tissue lysate. Recommended dilution: 1/500-2000. (Gel: 8%SDS-PAGE Lane 1: Jurkat cell lysate Lane 2: K562 cell lysate Lane 3: Bone marrow tissue lysate Lysates: 40 ug per lane Primary antibody: 1/500 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 minute)

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1:500-2000
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Fusion protein corresponding to a region derived from 125-450 amino acids of human mucosa associated lymphoid tissue lymphoma translocation gene 1
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 92 kDa
• Gene Name: MALT1 paracaspase
• Database Link:
  NP_006776
  Entrez Gene 240354 MouseEntrez Gene 307366 RatEntrez Gene 10892 Human
  UniProt ID Q9UDY8
• Background: Mucosa-associated lymphoid tissue translocation gene 1 (MALT1) is a paracaspase that is a critical mediator of T-cell receptor activation of NF-?B and may contribute to the progression of MALT lymphomas. It contains two immunoglobulin-like domains, an amino-terminal death domain and a carboxy-terminal caspase-like domain. Association of MALT1 with Bcl-10 and CARD11/Carma1 leads to activation of IKK and subsequent stimulation of NF-?B, resulting in increased proliferation and inhibition of apoptosis. A common translocation in MALT B-cell non-Hodgkin lymphomas t(11;18)(q21;q21) results in the fusion of the amino terminus of API2 (c-IAP2), a member of the inhibitor of apoptosis protein family, to the carboxy terminus of MALT1. The API2-MALT1 fusion protein likely leads to deregulation of NF-?B, contributing to increased oncogenic potential.
• Synonyms: IMD12; MLT; MLT1

Reference Data

• Protein Families: Druggable Genome, Protease
• Protein Pathways: B cell receptor signaling pathway, T cell receptor signaling pathway