ADAMTS5 Rabbit Polyclonal Antibody

CAT#: TA321798

Anti-ADAMTS5 Rabbit Polyclonal Antibody

Product Images

Predicted band size: 102kDa. Positive control: Human fetal brain tissue lysate. Recommended dilution: 1/500-2000. (Gel: 8%SDS-PAGE Lysate: 40 ug Primary antibody: 1/650 dilution Secondary antibody: Donkey anti Rabbit IgG - H&L (HRP) at 1/3000 dilution Exposure time: 3 seconds)

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  Predicted cell location: Cytoplasm, Cell membrane. Positive control: Human tonsil tissue. Recommended dilution: 1/10-50 The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using ADAMTS5 antibody at dilution 1/10, on the right is treated with the synthetic peptide. (Original magnification: x200)

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: ELISA: 1:1000-5000, WB: 1:500-2000, IHC: 1:10-50
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to a region derived from 529-541 amino acids of Human A disintegrin and metalloproteinase with thrombospondin motifs 5
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 102 kDa
• Gene Name: ADAM metallopeptidase with thrombospondin type 1 motif 5
• Database Link:
  NP_008969
  Entrez Gene 23794 MouseEntrez Gene 304135 RatEntrez Gene 11096 Human
  UniProt ID Q9UNA0
• Background: This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules; including a propeptide region; a metalloproteinase domain; a disintegrin-like domain; and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs; and some have unique C-terminal domains. The enzyme encoded by this gene contains two C-terminal TS motifs and functions as aggrecanase to cleave aggrecan; a major proteoglycan of cartilage.
• Synonyms: ADAM-TS 5; ADAM-TS5; ADAM-TS 11; ADAMTS-5; ADAMTS-11; ADAMTS11; ADMP-2

Reference Data

• Protein Families: Druggable Genome, Protease, Secreted Protein