ICOS Rabbit Polyclonal Antibody

CAT#: TA321805

Anti-ICOS Rabbit Polyclonal Antibody

Specifications

Product Data

• Applications: ELISA, IHC
• Recommended Dilution: IHC: 150-300
  Positive control: Human breast cancer
  Predicted cell location: Cytoplasm
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Fusion protein corresponding to a region derived from 21-140 amino acids of human inducible T-cell co-stimulator
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: inducible T-cell costimulator
• Database Link:
  NP_036224
  Entrez Gene 54167 MouseEntrez Gene 64545 RatEntrez Gene 29851 Human
  UniProt ID Q9Y6W8
• Background: The protein encoded by this gene belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers and plays an important role in cell-cell signaling; immune responses; and regulation of cell proliferation.?Enhances all basic T-cell responses to a foreign antigen; namely proliferation; secretion of lymphokines; up-regulation of molecules that mediate cell-cell interaction; and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2; but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes.
• Synonyms: AILIM; CD278; CVID1

Reference Data

• Protein Families: Secreted Protein, Transmembrane
• Protein Pathways: Cell adhesion molecules (CAMs), Primary immunodeficiency, T cell receptor signaling pathway