MCM4 Rabbit Polyclonal Antibody

CAT#: TA321984

Anti-MCM4 Rabbit Polyclonal Antibody


USD 345.00

In Stock*

Size
    • 100 ul

Other products for "MCM4"

Specifications

Product Data
Applications IHC, WB
Recommended Dilution WB: 500-2000
WB positive control: NIH/3T3, Hela and K562 cells
IHC: 50-200
Positive control: Human brain
Predicted cell location: Cytoplasm, Nucleus
Reactivities Human, Mouse, Rat
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen Synthetic peptide corresponding to a region derived from 837-850 amino acids of Human minichromosome maintenance complex component 4
Formulation PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration lot specific
Purification Antigen affinity purification
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Predicted Protein Size 97 kDa
Gene Name minichromosome maintenance complex component 4
Background The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2; 6 and 7 proteins possesses DNA helicase activity; and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. This gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK; a DNA-activated protein kinase involved in the repair of DNA double-strand breaks. Alternatively spliced transcript variants encoding the same protein have been reported.
Synonyms CDC21; CDC54; hCdc21; NKCD; NKGCD; P1-CDC21
Reference Data
Protein Families Stem cell - Pluripotency, Transcription Factors
Protein Pathways Cell cycle, DNA replication

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