DTX3 Rabbit Polyclonal Antibody

CAT#: TA321999

Anti-DTX3 rabbit polyclonal antibody

Specifications

Product Data

• Applications: ELISA, IHC, WB
• Recommended Dilution: WB: 200-1000
  WB positive control: SKOV3 cells
  IHC: 25-100
  Positive control: Human tonsil
  Predicted cell location: Cytoplasm
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Fusion protein corresponding to C terminal 248 amino acids of human deltex homolog 3 (Drosophila)
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 38 kDa
• Gene Name: deltex 3, E3 ubiquitin ligase
• Database Link:
  NP_848597
  Entrez Gene 80904 MouseEntrez Gene 500847 RatEntrez Gene 196403 Human
  UniProt ID Q8N9I9
• Background: DTX3 functions as an E3 ubiquitin ligase. It is regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Functions as an ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity.
• Synonyms: deltex3; RNF154

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Notch signaling pathway