ADAMTS10 Rabbit Polyclonal Antibody

CAT#: TA322159

Anti-ADAMTS10 Rabbit Polyclonal Antibody

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: IHC: 25-100
  Positive control: Human thyroid cancer
  Predicted cell location: Cytoplasm
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to a region derived from 1047-1074 amino acids of human ADAM metallopeptidase with thrombospondin type 1 motif, 10
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: ADAM metallopeptidase with thrombospondin type 1 motif 10
• Database Link:
  NP_112219
  Entrez Gene 224697 MouseEntrez Gene 314655 RatEntrez Gene 81794 Human
  UniProt ID Q9H324
• Background: This gene belongs to the ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin type-1 motifs) family of zinc-dependent proteases. ADAMTS proteases are complex secreted enzymes containing a prometalloprotease domain of the reprolysin type attached to an ancillary domain with a highly conserved structure that includes at least one thrombospondin type 1 repeat. They have been demonstrated to have important roles in connective tissue organization; coagulation; inflammation; arthritis; angiogenesis and cell migration. The product of this gene plays a major role in growth and in skin; lens; and heart development. It is also a candidate gene for autosomal recessive Weill-Marchesani syndrome.
• Synonyms: ADAM-TS10; ADAMTS-10; WMS; WMS1

Reference Data

• Protein Families: Druggable Genome, Secreted Protein