TRPM5 Rabbit Polyclonal Antibody

CAT#: TA322373

Anti-TRPM5 Rabbit Polyclonal Antibody

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB: 500-2000
  WB positive control: Mouse heart tissue
  IHC: 50-200
  Positive control: Human thyroid cancer
  Predicted cell location: Cytoplasm
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to a region derived from 1029-1043 amino acids of human transient receptor potential cation channel, subfamily M, member 5
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: transient receptor potential cation channel subfamily M member 5
• Database Link:
  NP_055370
  Entrez Gene 56843 MouseEntrez Gene 365391 RatEntrez Gene 29850 Human
  UniProt ID Q9NZQ8
• Background: This gene encodes a member of the transient receptor potential (TRP) protein family; which is a diverse group of proteins with structural features typical of ion channels. This protein plays an important role in taste transduction; and has characteristics of a calcium-activated; non-selective cation channel that carries Na+; K+; and Cs+ ions equally well; but not Ca(2+) ions. It is activated by lower concentrations of intracellular Ca(2+); and inhibited by higher concentrations. It is also a highly temperature-sensitive; heat activated channel showing a steep increase of inward currents at temperatures between 15 and 35 degrees Celsius. This gene is located within the Beckwith-Wiedemann syndrome critical region-1 on chromosome 11p15.5; and has been shown to be imprinted; with exclusive expression from the paternal allele.
• Synonyms: LTRPC5; MTR1

Reference Data

• Protein Families: Druggable Genome, Ion Channels: Transient receptor potential, Transmembrane
• Protein Pathways: Taste transduction