JAB1 (COPS5) Rabbit Polyclonal Antibody

CAT#: TA322462

Anti-COPS5 Rabbit Polyclonal Antibody

Specifications

Product Data

• Applications: ELISA, IHC, WB
• Recommended Dilution: WB: 1000-5000
  WB positive control: Mouse liver tissue
  IHC: 150-500
  Positive control: Human colon cancer
  Predicted cell location: Cytoplasm, Nucleus
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Full length fusion protein
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 38 kDa
• Gene Name: COP9 signalosome subunit 5
• Database Link:
  NP_006828
  Entrez Gene 26754 MouseEntrez Gene 312916 RatEntrez Gene 10987 Human
  UniProt ID Q92905
• Background: The protein encoded by this gene is one of the eight subunits of COP9 signalosome; a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be an coactivator that increases the specificity of JUN/AP1 transcription factors
• Synonyms: CSN5; JAB1; MOV-34; SGN5

Reference Data

• Protein Families: Druggable Genome, Protease, Transcription Factors