Noelin (OLFM1) Rabbit Polyclonal Antibody

CAT#: TA322511

Anti-OLFM1 Rabbit Polyclonal Antibody

Product Images

Predicted band size: 55 kDa. Positive control: Brain tissue; MCF7, A549 and SW480 cell lysate. Recommended dilution: 1/500-2000. (Gel: 10%SDS-PAGE Lane 1: Brain tissue lysate Lane 2: MCF7 cell lysate Lane 3: A549 cell lysate Lane 4: SW480 cell lysate Lysates: 40 ug per lane Primary antibody: 1/500 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 minute)

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  Predicted cell location: Secreted. Positive control: Lung cancer tissue. Recommended dilution: 1/50-200 The image is immunohistochemistry of paraffin-embedded Lung cancer tissue using OLFM1 antibody at dilution 1/50

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB: 1:500-2000
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Fusion protein corresponding to a region derived from 90-220 amino acids of human olfactomedin 1
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 55 kDa
• Gene Name: olfactomedin 1
• Database Link:
  NP_006325
  Entrez Gene 56177 MouseEntrez Gene 93667 RatEntrez Gene 10439 Human
  UniProt ID Q99784
• Background: The Olfactomedin family comprises a diverse group of secreted glycoproteins, which includes OLFM1 (Noelin-1), OLFM2 (Noelin-2), OLFM3 (Noelin-3), OLFM4 (Noelin-4), tiarin, pancortin, gliomedin and mycocilin. These proteins are implicated in the development of the nervous system. Specifically, OLFM1 and OLFM2 expression is observed in the neural plate and neural crest, as well as in the cranial ganglia in mouse at E8-10, and later in brain tissue and in the zone of polarizing activity in the limb. Overexpression of OLFM1 causes an excess of neural crest emigrations and prolonged neural crest production. OLFM2 participates in the regulation of the development of the anterior nervous system. An Arg144Gln mutation in OLFM2 has been implicated as a possible cause for open-angle glaucoma (OAG).
• Synonyms: AMY; NOE1; NOELIN1; OlfA

Reference Data

• Protein Families: Druggable Genome