MADH7 (SMAD7) Rabbit Polyclonal Antibody

CAT#: TA322546

Anti-SMAD7 rabbit polyclonal antibody

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB: 500-2000
  WB positive control: Mouse heart tissue lysate
  IHC: 40-200
  Positive control: Human esophagus cancer
  Predicted cell location: Nucleus and Cytoplasm
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to a region derived from 370-383 amino acids of Human SMAD family member 7
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 46 kDa
• Gene Name: SMAD family member 7
• Database Link:
  NP_005895
  Entrez Gene 17131 MouseEntrez Gene 81516 RatEntrez Gene 4092 Human
  UniProt ID O15105
• Background: The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene.
• Synonyms: CRCS3; MADH7; MADH8

Reference Data

• Protein Families: Druggable Genome, Transcription Factors
• Protein Pathways: TGF-beta signaling pathway