MADH7 (SMAD7) Rabbit Polyclonal Antibody

CAT#: TA322547

Anti-SMAD7 Rabbit Polyclonal Antibody


USD 345.00

In Stock*

Size
    • 100 ul

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Specifications

Product Data
Applications IHC
Recommended Dilution IHC: 50-200
Positive control: Human liver cancer
Predicted cell location: Cytoplasm, Nucleus
Reactivities Human, Mouse, Rat
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen Synthetic peptide corresponding to a region derived from 370-383 amino acids of Human SMAD family member 7
Formulation PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration lot specific
Purification Antigen affinity purification
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Gene Name SMAD family member 7
Background The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding; this complex translocates to the cytoplasm; where it interacts with TGF-beta receptor type-1 (TGFBR1); leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene.
Synonyms CRCS3; MADH7; MADH8
Reference Data
Protein Families Druggable Genome, Transcription Factors
Protein Pathways TGF-beta signaling pathway

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