LCN2 Rabbit Polyclonal Antibody

CAT#: TA322582

Anti-LCN2 Rabbit Polyclonal Antibody

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: IHC: 25-100
  Positive control: Human brain
  Predicted cell location: Cytoplasm
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide peptide corresponding to a region derived from 60-73 amino acids of human lipocalin 2
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: lipocalin 2
• Database Link:
  NP_005555
  Entrez Gene 16819 MouseEntrez Gene 170496 RatEntrez Gene 3934 Human
  UniProt ID P80188
• Background: Iron-trafficking protein involved in multiple processes such as apoptosis; innate immunity and renal development. Binds iron through association with 2;5-dihydroxybenzoic acid (2;5-DHBA); a siderophore that shares structural similarities with bacterial enterobactin; and delivers or removes iron from the cell; depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor; leading to release of iron and subsequent increase of intracellular iron concentration. In contrast; association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore; iron chelation and iron transfer to the extracellular medium; thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis; while iron-free form decreases intracellular iron levels; inducing expression of the proapoptotic protein BCL2L11/BIM; resulting in apoptosis. Involved in innate immunity; possibly by sequestrating iron; leading to limit bacterial growth.
• Synonyms: 24p3; MSFI; NGAL

Reference Data

• Protein Families: Secreted Protein