ABCA1 Rabbit Polyclonal Antibody

CAT#: TA322600

Anti-ABCA1 Rabbit Polyclonal Antibody

Product Images

Predicted band size: 254 kDa. Positive control: Raw264.7 cells lysate. Recommended dilution: 1/ 500-1000. (Gel: 8%SDS-PAGE Lysate: 30 ug Primary antibody: 1/500 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 minute)

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1:500-1000
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Peptide sequence around aa.2253~2257(D-E-K-V-K) derived from Human ABCA1.
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 254 kDa
• Gene Name: ATP binding cassette subfamily A member 1
• Database Link:
  NP_005493
  Entrez Gene 11303 MouseEntrez Gene 313210 RatEntrez Gene 19 Human
  UniProt ID O95477
• Background: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. With cholesterol as its substrate, this protein functions as a cholesteral efflux pump in the cellular lipid removal pathway. Mutations in this gene have been associated with Tangier's disease and familial high-density lipoprotein deficiency.
• Synonyms: ABC-1; ABC1; CERP; HDLDT1; TGD

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: ABC transporters