ROCK2 Rabbit Polyclonal Antibody

CAT#: TA322699

Anti-ROCK2 Rabbit Polyclonal Antibody


USD 345.00

In Stock*

Size
    • 100 ul

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Specifications

Product Data
Applications ELISA, IHC
Recommended Dilution IHC: 25-100
Positive control: Human cervical cancer
Predicted cell location: Cytoplasm, Nucleus
Reactivities Human, Mouse, Rat
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen Fusion protein corresponding to C terminal 300 amino acids of human Rho-associated, coiled-coil containing protein kinase 2
Formulation PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration lot specific
Purification Antigen affinity purification
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Gene Name Rho associated coiled-coil containing protein kinase 2
Background The protein encoded by this gene is a serine/threonine kinase that regulates cytokinesis; smooth muscle contraction; the formation of actin stress fibers and focal adhesions; and the activation of the c-fos serum response element. This protein; which is an isozyme of ROCK1 is a target for the small GTPase Rho. Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction; actin cytoskeleton organization; stress fiber and focal adhesion formation; neurite retraction; cell adhesion and motility via phosphorylation of ADD1; BRCA2; CNN1; EZR; DPYSL2; EP300; MSN; MYL9/MLC2; NPM1; RDX; PPP1R12A and VIM. Phosphorylates SORL1 and IRF4.
Synonyms ROCK-II
Reference Data
Protein Families Druggable Genome, Protein Kinase
Protein Pathways Axon guidance, Chemokine signaling pathway, Focal adhesion, Leukocyte transendothelial migration, Pathogenic Escherichia coli infection, Regulation of actin cytoskeleton, TGF-beta signaling pathway, Vascular smooth muscle contraction, Wnt signaling pathway

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