IKB epsilon (NFKBIE) Rabbit Polyclonal Antibody

CAT#: TA322728

Anti-NFKBIE Rabbit Polyclonal Antibody


USD 345.00

In Stock*

Size
    • 100 ul

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Specifications

Product Data
Applications ELISA, IHC, WB
Recommended Dilution WB: 200-1000
WB positive control: Raji cells
IHC: 50-200
Positive control: Human esophagus cancer
Predicted cell location: Cytoplasm
Reactivities Human, Mouse, Rat
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen Fusion protein corresponding to a region derived from 63-423 amino acids of human nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
Formulation PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration lot specific
Purification Antigen affinity purification
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Predicted Protein Size 45 kDa
Gene Name NFKB inhibitor epsilon
Background The protein encoded by this gene binds to components of NF-kappa-B; trapping the complex in the cytoplasm and preventing it from activating genes in the nucleus. Phosphorylation of the encoded protein targets it for destruction by the ubiquitin pathway; which activates NF-kappa-B by making it available to translocate to the nucleus. NFKBIE protein expression is up-regulated following NF-?B activation and during myelopoiesis. NFKBIE is able to inhibit NF-?B-directed transactivation via cytoplasmic retention of REL proteins. NFKB1 or NFKB2 is bound to REL; RELA; or RELB to form the NF-?B transcription factor complex. The NF-?B complex is inhibited by I-kappa-B proteins (NFKBIA or NFKBIB); which inactivate NF-kappa-B by trapping it in the cytoplasm.
Synonyms IKBE
Reference Data
Protein Families Druggable Genome, Transcription Factors
Protein Pathways Adipocytokine signaling pathway, B cell receptor signaling pathway, Neurotrophin signaling pathway, T cell receptor signaling pathway

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