IKB epsilon (NFKBIE) Rabbit Polyclonal Antibody

CAT#: TA322728

Anti-NFKBIE Rabbit Polyclonal Antibody

Specifications

Product Data

• Applications: ELISA, IHC, WB
• Recommended Dilution: WB: 200-1000
  WB positive control: Raji cells
  IHC: 50-200
  Positive control: Human esophagus cancer
  Predicted cell location: Cytoplasm
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Fusion protein corresponding to a region derived from 63-423 amino acids of human nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 45 kDa
• Gene Name: NFKB inhibitor epsilon
• Database Link:
  NP_004547
  Entrez Gene 18037 MouseEntrez Gene 316241 RatEntrez Gene 4794 Human
  UniProt ID O00221
• Background: The protein encoded by this gene binds to components of NF-kappa-B; trapping the complex in the cytoplasm and preventing it from activating genes in the nucleus. Phosphorylation of the encoded protein targets it for destruction by the ubiquitin pathway; which activates NF-kappa-B by making it available to translocate to the nucleus. NFKBIE protein expression is up-regulated following NF-?B activation and during myelopoiesis. NFKBIE is able to inhibit NF-?B-directed transactivation via cytoplasmic retention of REL proteins. NFKB1 or NFKB2 is bound to REL; RELA; or RELB to form the NF-?B transcription factor complex. The NF-?B complex is inhibited by I-kappa-B proteins (NFKBIA or NFKBIB); which inactivate NF-kappa-B by trapping it in the cytoplasm.
• Synonyms: IKBE

Reference Data

• Protein Families: Druggable Genome, Transcription Factors
• Protein Pathways: Adipocytokine signaling pathway, B cell receptor signaling pathway, Neurotrophin signaling pathway, T cell receptor signaling pathway